Single-site chemical modification at C10 of the baccatin III core of paclitaxel and taxol C reduces P-glycoprotein interactions in bovine brain microvessel endothelial cells
- Auteur
- SPLETSTOSER, Jared T1 ; TURUNEN, Brandon J1 ; GEORG, Gunda I1 ; DESINO, Kelly2 ; RICE, Antonie2 ; DATTA, Apurba1 ; DUTTA, Dinah1 ; HUFF, Jacquelyn K3 ; HIMES, Richard H3 ; AUDUS, Kenneth L2 ; SEELIG, Anna4
[1] Department of Medicinal Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States
[2] Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047, United States
[3] Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045, United States
[4] Department of Biophysical Chemistry, Biocenter of the University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland - Source
Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 3, pp 495-498, 4 p ; ref : ½ p. ref. et notes
- ISSN
- 0960-894X
- Domaine scientifique
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Editeur
- Elsevier, Oxford
- Pays de publication
- United Kingdom
- Type de document
- Article
- Langue
- English
- Mot clé auteur
- 10-Deacetylpaclitaxel 10-epi-Paclitaxel Blood-brain barrier P-glycoprotein Paclitaxel
- Mot clé (fr)
- Animal Anticancéreux Antimitotique Antitubuline Barrière hématoencéphalique Bovin Cellule endothéliale Cellule tumorale Cytotoxicité Diterpène Encéphale Glycoprotéine P In vitro Lignée cellulaire Modification chimique Paclitaxel Perméabilité cellulaire Protéine transmembranaire Protéine transport Relation structure activité Synthèse chimique Système nerveux central Taxane dérivé Terpénoïde Transport biologique Taxol dérivé Artiodactyla Mammalia Ungulata Vertebrata
- Mot clé (en)
- Animal Antineoplastic agent Antimitotic Antitubulin Blood brain barrier Bovine Endothelial cell Tumor cell Cytotoxicity Diterpene Encephalon P Glycoprotein In vitro Cell line Chemical modification Paclitaxel Cell permeability Transmembrane protein Carrier protein Structure activity relation Chemical synthesis Central nervous system Taxane derivatives Terpenoid Biological transport Artiodactyla Mammalia Ungulata Vertebrata
- Mot clé (es)
- Animal Anticanceroso Antimitótico Antitubulina Barrera hematoencefálica Bovino Célula endotelial Célula tumoral Citotoxicidad Diterpeno Encéfalo Glicoproteína P In vitro Línea celular Modificación química Paclitaxel Permeabilidad celular Proteína transmembranar Proteína transportador Relación estructura actividad Síntesis química Sistema nervioso central Taxane derivado Terpenoide Transporte biológico Artiodactyla Mammalia Ungulata Vertebrata
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02R Anticancéreux / 002B02R01 Généralités
- Discipline
- Pharmacological treatments
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 17391028
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmcl.2005.10.063 
https://dx.doi.org/10.1016/j.bmcl.2005.10.063
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