Internal tandem duplication of FLT3 (FLT3/ITD) induces increased ROS production, DNA damage, and misrepair : implications for poor prognosis in AML
- Auteur
- SALLMYR, Annahita1 ; JINSHUI FAN1 ; DATTA, Kamal1 ; KIM, Kyu-Tae2 ; GROSU, Dan1 ; SHAPIRO, Paul3 ; SMALL, Donald2 ; RASSOOL, Feyruz1
[1] Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore, United States
[2] Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, United States
[3] School of Pharmacy, University of Maryland, Baltimore, United States - Source
Blood. 2008, Vol 111, Num 6, pp 3173-3182, 10 p ; ref : 64 ref
- ISSN
- 0006-4971
- Domaine scientifique
- Medical oncology; Hematology
- Editeur
- The Americain Society of Hematology, Washington, DC
- Pays de publication
- United States
- Type de document
- Article
- Langue
- English
- Mot clé (fr)
- Cassure bicaténaire DNA Duplication génique Espèces réactives de l'oxygène Facteur transcription STAT5 Gène onc cellulaire Homme Hématologie Leucémie aiguë myéloblastique Lésion Mutation Mésappariement base Pronostic Transduction signal Duplication interne en tandem Gène FLT3 Récepteur tyrosine kinase Cancer Génétique Hémopathie maligne
- Mot clé (en)
- Double strand break DNA Gene duplication Reactive oxygen species Transcription factor STAT5 C-Onc gene Human Hematology Acute myelogenous leukemia Lesion Mutation Base mismatching Prognosis Signal transduction Internal tandem duplication FLT3 gene Receptor tyrosine kinase Cancer Genetics Malignant hemopathy
- Mot clé (es)
- Ruptura bicatenaria DNA Duplicación génica Especies reactivas del oxígeno Factor transcripción STAT5 Gen onc celular Hombre Hematología Leucemia aguda mieloblástica Lesión Mutación Desapareamiento base Pronóstico Transducción señal Cáncer Genética Hemopatía maligna
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B19 Hemopathies / 002B19B Leucémies. Lymphomes malins. Réticuloses malignes. Hématodermies. Splénomégalie myéloïde
- Discipline
- Blood diseases
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 20181496
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1182/blood-2007-05-092510 
https://dx.doi.org/10.1182/blood-2007-05-092510
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