AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
- Author
- HUYNH, Hung1 ; VAN CHANH NGO1 ; BOON CHER GOH6 ; SMITH, Paul D7 ; KHEE CHEE SOO1 ; HENG NUNG KOONG2 ; POON, Donald3 ; SU PIN CHOO3 ; HAN CHONG TOH3 ; CHOON HUA THNG4 ; CHOW, Pierce5 ; HOCK SOO ONG5 ; CHUNG, Alexander5
[1] Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[2] Department of Surgical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[3] Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[4] Department of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[5] Department of General Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
[6] National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
[7] Cancer and Infection, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK104TG, United Kingdom - Source
Journal of hepatology. 2010, Vol 52, Num 1, pp 79-87, 9 p ; ref : 44 ref
- CODEN
- JOHEEC
- ISSN
- 0168-8278
- Scientific domain
- Gastroenterology
- Publisher
- Elsevier, Kidlington
- Publication country
- United Kingdom
- Document type
- Article
- Language
- English
- Author keyword
- Angiogenesis Apoptosis Combined therapy Growth inhibition HCC xenografts
- Keyword (fr)
- Angiogenèse Antiangiogénique Anticancéreux Apoptose Carcinome hépatocellulaire Croissance Ectopie Gastroentérologie Homme Hétérogreffe Modèle Sorafénib Traitement associé Cancer Greffe Inhibiteur de la tyrosine kinase Inhibiteur enzyme Inhibiteur multikinase Pathologie de l'appareil digestif Pathologie du foie Tumeur maligne
- Keyword (en)
- Angiogenesis Antiangiogenic agent Antineoplastic agent Apoptosis Hepatocellular carcinoma Growth Ectopia Gastroenterology Human Heterograft Models Sorafenib Combined treatment Cancer Graft Tyrosine kinase inhibitor Enzyme inhibitor Multikinase inhibitor Digestive diseases Hepatic disease Malignant tumor
- Keyword (es)
- Angiogénesis Antiangiogenico Anticanceroso Apoptosis Carcinoma hepatocelular Crecimiento Ectopia Gastroenterología Hombre Heteroinjerto Modelo Sorafenib Tratamiento asociado Cáncer Injerto Inhibidor tyrosine kinase Inhibidor enzima inhibidor multicinasa Aparato digestivo patología Hígado patología Tumor maligno
- Classification
- Pascal
- 002 Biological and medical sciences / 002B Medical sciences / 002B13 Gastroenterology. Liver. Pancreas. Abdomen / 002B13C Liver. Biliary tract. Portal circulation. Exocrine pancreas / 002B13C01 Tumors
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen
- Origin
- Inist-CNRS
- Database
- PASCAL
- INIST identifier
- 22275367
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.jhep.2009.10.008 
https://dx.doi.org/10.1016/j.jhep.2009.10.008
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