AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)
- Auteur
- HUYNH, Hung1 ; VAN CHANH NGO1 ; BOON CHER GOH6 ; SMITH, Paul D7 ; KHEE CHEE SOO1 ; HENG NUNG KOONG2 ; POON, Donald3 ; SU PIN CHOO3 ; HAN CHONG TOH3 ; CHOON HUA THNG4 ; CHOW, Pierce5 ; HOCK SOO ONG5 ; CHUNG, Alexander5
[1] Laboratory of Molecular Endocrinology, Division of Molecular and Cellular Research, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[2] Department of Surgical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[3] Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[4] Department of Oncologic Imaging, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore
[5] Department of General Surgery, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
[6] National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore
[7] Cancer and Infection, AstraZeneca, Alderley Park, Macclesfield, Cheshire SK104TG, United Kingdom - Source
Journal of hepatology. 2010, Vol 52, Num 1, pp 79-87, 9 p ; ref : 44 ref
- CODEN
- JOHEEC
- ISSN
- 0168-8278
- Domaine scientifique
- Gastroenterology
- Editeur
- Elsevier, Kidlington
- Pays de publication
- United Kingdom
- Type de document
- Article
- Langue
- English
- Mot clé auteur
- Angiogenesis Apoptosis Combined therapy Growth inhibition HCC xenografts
- Mot clé (fr)
- Angiogenèse Antiangiogénique Anticancéreux Apoptose Carcinome hépatocellulaire Croissance Ectopie Gastroentérologie Homme Hétérogreffe Modèle Sorafénib Traitement associé Cancer Greffe Inhibiteur de la tyrosine kinase Inhibiteur enzyme Inhibiteur multikinase Pathologie de l'appareil digestif Pathologie du foie Tumeur maligne
- Mot clé (en)
- Angiogenesis Antiangiogenic agent Antineoplastic agent Apoptosis Hepatocellular carcinoma Growth Ectopia Gastroenterology Human Heterograft Models Sorafenib Combined treatment Cancer Graft Tyrosine kinase inhibitor Enzyme inhibitor Multikinase inhibitor Digestive diseases Hepatic disease Malignant tumor
- Mot clé (es)
- Angiogénesis Antiangiogenico Anticanceroso Apoptosis Carcinoma hepatocelular Crecimiento Ectopia Gastroenterología Hombre Heteroinjerto Modelo Sorafenib Tratamiento asociado Cáncer Injerto Inhibidor tyrosine kinase Inhibidor enzima inhibidor multicinasa Aparato digestivo patología Hígado patología Tumor maligno
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B13 Gastroenterologie. Foie. Pancreas. Abdomen / 002B13C Foie. Voies biliaires. Circulation portale. Pancréas exocrine / 002B13C01 Tumeurs
- Discipline
- Gastroenterology. Liver. Pancreas. Abdomen
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 22275367
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
Accès au Document
Installer sur votre navigateur
DOI
10.1016/j.jhep.2009.10.008 
https://dx.doi.org/10.1016/j.jhep.2009.10.008
"O:13:\"PanistOpenUrl\":36:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000idc\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.jhep.2009.10.008\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:9:\"\u0000*\u0000jtitle\";s:21:\"Journal of hepatology\";s:9:\"\u0000*\u0000stitle\";s:10:\"J. hepatol\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:2:\"79\";s:8:\"\u0000*\u0000epage\";s:2:\"87\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0168-8278\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"HUYNH\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Hung\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:13:\"VAN CHANH NGO\";i:1;s:13:\"BOON CHER GOH\";i:2;s:13:\"SMITH, Paul D\";i:3;s:13:\"KHEE CHEE SOO\";i:4;s:15:\"HENG NUNG KOONG\";i:5;s:12:\"POON, Donald\";i:6;s:11:\"SU PIN CHOO\";i:7;s:13:\"HAN CHONG TOH\";i:8;s:14:\"CHOON HUA THNG\";i:9;s:12:\"CHOW, Pierce\";i:10;s:12:\"HOCK SOO ONG\";i:11;s:16:\"CHUNG, Alexander\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JOHEEC\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:8:\"\u0000*\u0000place\";s:10:\"Kidlington\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Accès par Panist
"O:12:\"IstexOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.jhep.2009.10.008\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:9:\"\u0000*\u0000jtitle\";s:21:\"Journal of hepatology\";s:9:\"\u0000*\u0000stitle\";s:10:\"J. hepatol\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:2:\"79\";s:8:\"\u0000*\u0000epage\";s:2:\"87\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0168-8278\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"HUYNH\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Hung\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:13:\"VAN CHANH NGO\";i:1;s:13:\"BOON CHER GOH\";i:2;s:13:\"SMITH, Paul D\";i:3;s:13:\"KHEE CHEE SOO\";i:4;s:15:\"HENG NUNG KOONG\";i:5;s:12:\"POON, Donald\";i:6;s:11:\"SU PIN CHOO\";i:7;s:13:\"HAN CHONG TOH\";i:8;s:14:\"CHOON HUA THNG\";i:9;s:12:\"CHOW, Pierce\";i:10;s:12:\"HOCK SOO ONG\";i:11;s:16:\"CHUNG, Alexander\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JOHEEC\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:8:\"\u0000*\u0000place\";s:10:\"Kidlington\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Accès par Istex
"O:16:\"UnpaywallOpenUrl\":35:{s:8:\"\u0000*\u0000email\";s:27:\"assistance-portail@inist.fr\";s:6:\"\u0000*\u0000fmt\";N;s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.jhep.2009.10.008\";s:6:\"\u0000*\u0000pii\";N;s:7:\"\u0000*\u0000pmid\";N;s:9:\"\u0000*\u0000atitle\";N;s:9:\"\u0000*\u0000jtitle\";N;s:9:\"\u0000*\u0000stitle\";N;s:7:\"\u0000*\u0000date\";N;s:9:\"\u0000*\u0000volume\";N;s:8:\"\u0000*\u0000issue\";N;s:8:\"\u0000*\u0000spage\";N;s:8:\"\u0000*\u0000epage\";N;s:8:\"\u0000*\u0000pages\";N;s:7:\"\u0000*\u0000issn\";N;s:8:\"\u0000*\u0000eissn\";N;s:9:\"\u0000*\u0000aulast\";N;s:10:\"\u0000*\u0000aufirst\";N;s:9:\"\u0000*\u0000auinit\";N;s:10:\"\u0000*\u0000auinitm\";N;s:5:\"\u0000*\u0000au\";N;s:9:\"\u0000*\u0000aucorp\";N;s:7:\"\u0000*\u0000isbn\";N;s:8:\"\u0000*\u0000coden\";N;s:8:\"\u0000*\u0000genre\";N;s:7:\"\u0000*\u0000part\";N;s:9:\"\u0000*\u0000btitle\";N;s:8:\"\u0000*\u0000title\";N;s:8:\"\u0000*\u0000place\";N;s:6:\"\u0000*\u0000pub\";N;s:10:\"\u0000*\u0000edition\";N;s:9:\"\u0000*\u0000tpages\";N;s:9:\"\u0000*\u0000series\";N;s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";N;}"
Accès par Unpaywall
"O:16:\"EuropePMCOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.jhep.2009.10.008\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:9:\"\u0000*\u0000jtitle\";s:21:\"Journal of hepatology\";s:9:\"\u0000*\u0000stitle\";s:10:\"J. hepatol\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:2:\"79\";s:8:\"\u0000*\u0000epage\";s:2:\"87\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0168-8278\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"HUYNH\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Hung\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:13:\"VAN CHANH NGO\";i:1;s:13:\"BOON CHER GOH\";i:2;s:13:\"SMITH, Paul D\";i:3;s:13:\"KHEE CHEE SOO\";i:4;s:15:\"HENG NUNG KOONG\";i:5;s:12:\"POON, Donald\";i:6;s:11:\"SU PIN CHOO\";i:7;s:13:\"HAN CHONG TOH\";i:8;s:14:\"CHOON HUA THNG\";i:9;s:12:\"CHOW, Pierce\";i:10;s:12:\"HOCK SOO ONG\";i:11;s:16:\"CHUNG, Alexander\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JOHEEC\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:8:\"\u0000*\u0000place\";s:10:\"Kidlington\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Accès par Europe PubMed Central
"O:11:\"BaseOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.jhep.2009.10.008\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:9:\"\u0000*\u0000jtitle\";s:21:\"Journal of hepatology\";s:9:\"\u0000*\u0000stitle\";s:10:\"J. hepatol\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:2:\"79\";s:8:\"\u0000*\u0000epage\";s:2:\"87\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0168-8278\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"HUYNH\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Hung\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:13:\"VAN CHANH NGO\";i:1;s:13:\"BOON CHER GOH\";i:2;s:13:\"SMITH, Paul D\";i:3;s:13:\"KHEE CHEE SOO\";i:4;s:15:\"HENG NUNG KOONG\";i:5;s:12:\"POON, Donald\";i:6;s:11:\"SU PIN CHOO\";i:7;s:13:\"HAN CHONG TOH\";i:8;s:14:\"CHOON HUA THNG\";i:9;s:12:\"CHOW, Pierce\";i:10;s:12:\"HOCK SOO ONG\";i:11;s:16:\"CHUNG, Alexander\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JOHEEC\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:8:\"\u0000*\u0000place\";s:10:\"Kidlington\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Accès par Base Search
"O:12:\"ArXivOpenUrl\":35:{s:10:\"\u0000*\u0000openUrl\";N;s:6:\"\u0000*\u0000fmt\";s:7:\"journal\";s:6:\"\u0000*\u0000doi\";s:26:\"10.1016\/j.jhep.2009.10.008\";s:6:\"\u0000*\u0000pii\";s:0:\"\";s:7:\"\u0000*\u0000pmid\";s:0:\"\";s:9:\"\u0000*\u0000atitle\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:9:\"\u0000*\u0000jtitle\";s:21:\"Journal of hepatology\";s:9:\"\u0000*\u0000stitle\";s:10:\"J. hepatol\";s:7:\"\u0000*\u0000date\";s:4:\"2010\";s:9:\"\u0000*\u0000volume\";s:2:\"52\";s:8:\"\u0000*\u0000issue\";s:1:\"1\";s:8:\"\u0000*\u0000spage\";s:2:\"79\";s:8:\"\u0000*\u0000epage\";s:2:\"87\";s:8:\"\u0000*\u0000pages\";s:0:\"\";s:7:\"\u0000*\u0000issn\";s:9:\"0168-8278\";s:8:\"\u0000*\u0000eissn\";s:0:\"\";s:9:\"\u0000*\u0000aulast\";s:5:\"HUYNH\";s:10:\"\u0000*\u0000aufirst\";s:4:\"Hung\";s:9:\"\u0000*\u0000auinit\";s:0:\"\";s:10:\"\u0000*\u0000auinitm\";s:0:\"\";s:5:\"\u0000*\u0000au\";a:12:{i:0;s:13:\"VAN CHANH NGO\";i:1;s:13:\"BOON CHER GOH\";i:2;s:13:\"SMITH, Paul D\";i:3;s:13:\"KHEE CHEE SOO\";i:4;s:15:\"HENG NUNG KOONG\";i:5;s:12:\"POON, Donald\";i:6;s:11:\"SU PIN CHOO\";i:7;s:13:\"HAN CHONG TOH\";i:8;s:14:\"CHOON HUA THNG\";i:9;s:12:\"CHOW, Pierce\";i:10;s:12:\"HOCK SOO ONG\";i:11;s:16:\"CHUNG, Alexander\";}s:9:\"\u0000*\u0000aucorp\";s:0:\"\";s:7:\"\u0000*\u0000isbn\";s:0:\"\";s:8:\"\u0000*\u0000coden\";s:6:\"JOHEEC\";s:8:\"\u0000*\u0000genre\";s:7:\"article\";s:7:\"\u0000*\u0000part\";s:0:\"\";s:9:\"\u0000*\u0000btitle\";s:0:\"\";s:8:\"\u0000*\u0000title\";s:126:\"AZD6244 enhances the anti-tumor activity of sorafenib in ectopic and orthotopic models of human hepatocellular carcinoma (HCC)\";s:8:\"\u0000*\u0000place\";s:10:\"Kidlington\";s:6:\"\u0000*\u0000pub\";s:8:\"Elsevier\";s:10:\"\u0000*\u0000edition\";s:0:\"\";s:9:\"\u0000*\u0000tpages\";s:1:\"9\";s:9:\"\u0000*\u0000series\";s:0:\"\";s:8:\"\u0000*\u0000proxy\";s:30:\"http:\/\/proxyout.inist.fr:8080\/\";s:12:\"\u0000*\u0000integrite\";b:1;}"
Accès par arXiv
