Structure—Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections
- Auteur
- JIANGNAN PENG1 ; KUDRIMOTI, Sucheta1 ; KHAN, Shabana I1 3 ; BIN WANG1 ; MAYER, Alejandro M. S4 ; JACOB, Melissa R3 ; TU, Lan Chun5 ; GERTSCH, Jürg6 7 ; HAMANN, Mark T1 3 ; PRASANNA, Sivaprakasam2 ; ODDE, Srinivas2 ; DOERKSEN, Robert J1 3 ; PENNAKA, Hari K1 ; CHOO, Yeun-Mun1 ; RAO, Karumanchi V1 ; TEKWANI, Babu L3 ; MADGULA, Vamsi3
[1] Department of Pharmacognosy, The University of Mississippi, Oxford, Mississippi 38677, United States
[2] Department of Medicinal Chemistry, The University of Mississippi, Oxford, Mississippi 38677, United States
[3] National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Oxford, Mississippi 38677, United States
[4] Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, Illinois 60515, United States
[5] Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan, Province of China
[6] Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland
[7] Institute of Biochemistry and Molecular Medicine, University of Bern, 3012 Bern, Switzerland - Source
Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 61-76, 16 p ; ref : 72 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Domaine scientifique
- Pharmacology drugs
- Editeur
- American Chemical Society, Columbus, OH
- Pays de publication
- United States
- Type de document
- Article
- Langue
- English
- Mot clé (fr)
- Alcaloïde Animal Antibactérien Antifongique Antiinflammatoire Antipaludique Antiparasitaire Antiprotozoaire Barrière hématoencéphalique Inflammation Mode liaison Modèle moléculaire Modélisation Mécanisme action Phénols Relation structure activité Tau-protein kinase 9a,13-Méthanoazacycloundécino[3,2-e]azacyclopentadécine dérivé EC 2-7-11-26 Manzamine Méthanoazacycloundécinoazacyclopentadécine Pyrido[3,4-b]indole dérivé Pyridoindole Enzyme Transferases
- Mot clé (en)
- Alkaloid Animal Antibacterial agent Antifungal agent Antiinflammatory agent Antimalarial Parasiticide Antiprotozoal agent Blood brain barrier Inflammation Binding mode Molecular model Modeling Mechanism of action Phenols Structure activity relation Tau-protein kinase Enzyme Transferases
- Mot clé (es)
- Alcaloide Animal Antibacteriano Antifúngico Antiinflamatorio Antipalúdico Antiparasitario Antiprotozoario Barrera hematoencefálica Inflamación Modo de enlace Modelo molecular Modelización Mecanismo acción Fenoles Relación estructura actividad Tau-protein kinase Enzima Transferases
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02L Os, articulations et tissu conjonctif. Antiinflammatoires
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S02 Antibactériens
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S04 Antifongiques
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S06 Antiparasitaires
- Discipline
- Pharmacological treatments
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 22361871
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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