Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 arginine Mimetics
- Auteur
- BECKER, Gero. L1 ; SIELAFF, Frank1 ; THAN, Manuel E2 ; LINDBERG, Iris3 ; ROUTHIER, Sophie1 ; DAY, Robert4 ; YINGHUI LU5 ; GARTEN, Wolfgang5 ; STEINMETZER, Torsten1
[1] Institute of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, 35032 Marburg, Germany
[2] Leibniz Institute for Age Research-Fritz Lipmann Institute(FLI), Protein Crystallography Group, Beutenhergstrasse 11, 07745 Jena, Germany
[3] Department of Anatomy and Neurrobiology, Universily of Maryland, Baltimore, Maryland 21201, United States
[4] Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke. Québec, JIH 5N4, Canada
[5] Institule of Virology, Philipps University Marburg, Hans-Meerwein-Strasse 2, 35043 Marburg, Germany - Source
Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1067-1075, 9 p ; ref : 52 ref
- CODEN
- JMCMAR
- ISSN
- 0022-2623
- Domaine scientifique
- Pharmacology drugs
- Editeur
- American Chemical Society, Columbus, OH
- Pays de publication
- United States
- Type de document
- Article
- Langue
- English
- Mot clé (fr)
- Activité biologique Amidine Furin In vitro Inhibiteur enzyme Mimétique Mode liaison Modèle moléculaire Modélisation Peptide Synthèse chimique Tripeptide α-Aminoacide Arginine dérivé Benzamidine(4-[phénylacétyl-arginyl-valyl-argiinylaminométhyl]) Enzyme Hydrolases Peptidases Serine endopeptidases
- Mot clé (en)
- Biological activity Amidine Furin In vitro Enzyme inhibitor Mimetic Binding mode Molecular model Modeling Peptides Chemical synthesis Tripeptide α-Aminoacid Enzyme Hydrolases Peptidases Serine endopeptidases
- Mot clé (es)
- Actividad biológica Amidina Furin In vitro Inhibidor enzima Mimético Modo de enlace Modelo molecular Modelización Péptido Síntesis química Tripéptido α-Aminoácido Enzima Hydrolases Peptidases Serine endopeptidases
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02B Neuropharmacologie / 002B02B11 Divers
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02N Métabolisme général et cellulaire. Vitamines
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02R Anticancéreux / 002B02R01 Généralités
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S05 Antiviraux
- Discipline
- Pharmacological treatments
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 22454115
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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