Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens
- Auteur
- BAG, Seema1 ; TAWARI, Nilesh R1 ; DEGANI, Mariam S1 ; QUEENER, Sherry F2
[1] Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga (E), Mumbai 400 019, India
[2] Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, IN 46202, United States - Source
Bioorganic & medicinal chemistry. 2010, Vol 18, Num 9, pp 3187-3197, 11 p ; ref : 28 ref
- ISSN
- 0968-0896
- Domaine scientifique
- Biochemistry, molecular biology, biophysics; Pharmacology drugs
- Editeur
- Elsevier, Amsterdam
- Pays de publication
- Netherlands
- Type de document
- Article
- Langue
- English
- Mot clé auteur
- 2,4-Diaminopyrimidine Dihydrofolate reductase Docking MM-GBSA
- Mot clé (fr)
- Antibactérien Antifolate Antifongique Antiinfectieux Antimétabolite Antiparasitaire Antiprotozoaire Complexe enzyme inhibiteur Dihydrofolate reductase Dérivé de la pyrimidine In vitro Infection opportuniste Inhibiteur enzyme Mode liaison Modèle moléculaire Modélisation Mycobacterium avium Pneumocystis carinii Relation structure activité Synthèse chimique Toxoplasma gondii Actinomycetes Apicomplexa Bactérie Enzyme Fungi Imperfecti Fungi Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Mot clé (en)
- Antibacterial agent Antifolate Antifungal agent Antiinfectious Antimetabolic Parasiticide Antiprotozoal agent Inhibitor enzyme complex Dihydrofolate reductase Pyrimidine derivatives In vitro Opportunistic infection Enzyme inhibitor Binding mode Molecular model Modeling Mycobacterium avium Pneumocystis carinii Structure activity relation Chemical synthesis Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enzyme Fungi Imperfecti Fungi Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Mot clé (es)
- Antibacteriano Antifolato Antifúngico Antiinfeccioso Antimetabólito Antiparasitario Antiprotozoario Complejo enzima inhibidor Dihydrofolate reductase Pirimidina derivado In vitro Infección oportunista Inhibidor enzima Modo de enlace Modelo molecular Modelización Mycobacterium avium Pneumocystis carinii Relación estructura actividad Síntesis química Toxoplasma gondii Actinomycetes Apicomplexa Bacteria Enzima Fungi Imperfecti Fungi Mycobacteriaceae Mycobacteriales Oxidoreductases Protozoa
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S01 Généralités
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S02 Antibactériens
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S04 Antifongiques
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S06 Antiparasitaires
- Discipline
- Pharmacological treatments
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 22891292
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1016/j.bmc.2010.03.031 
https://dx.doi.org/10.1016/j.bmc.2010.03.031
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