Antiretroviral efficacy and pharmacokinetics of oral bis(isopropyloxycarbonyloxymethyl)-9-(2-phosphonylmethoxypropyl )adenine in mice
- Auteur
- NAESENS, L1 ; BISCHOFBERGER, N2 ; AUGUSTIJNS, P3 ; ANNAERT, P3 ; VAN DEN MOOTER, G3 ; ARIMILLI, M. N2 ; KIM, C. U2 ; DE CLERCQ, E1
[1] Rega Institute for Medical Research, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
[2] Gilead Sciences, Inc., Foster City, California 944042, United States
[3] Laboratory for Pharmacotechnology and Biopharmacy, Katholieke Universiteit Leuven, 3000 Leuven, Belgium - Source
Antimicrobial agents and chemotherapy. 1998, Vol 42, Num 7, pp 1568-1573 ; ref : 20 ref
- CODEN
- AACHAX
- ISSN
- 0066-4804
- Domaine scientifique
- Microbiology, infectious diseases; Pharmacology drugs
- Editeur
- American Society for Microbiology, Washington, DC
- Pays de publication
- United States
- Type de document
- Article
- Langue
- English
- Mot clé (fr)
- Activité biologique Adénine dérivé Animal Antiviral Biodisponibilité Ester In vitro In vivo Lignée cellulaire établie Métabolisme Perméabilité Pharmacocinétique Promédicament Souris Toxicité Transport biologique Voie orale Lignée CACO2 Mammalia Rodentia Vertebrata
- Mot clé (en)
- Biological activity Adenine derivatives Animal Antiviral Bioavailability Ester In vitro In vivo Established cell line Metabolism Permeability Pharmacokinetics Prodrug Mouse Toxicity Biological transport Oral administration Mammalia Rodentia Vertebrata
- Mot clé (es)
- Actividad biológica Adenina derivado Animal Antiviral Biodisponibilidad Ester In vitro In vivo Línea celular establecida Metabolismo Permeabilidad Farmacocinética Promedicamento Ratón Toxicidad Transporte biológico Vía oral Mammalia Rodentia Vertebrata
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02S Antibiotiques. Antiinfectieux. Antiparasitaires / 002B02S05 Antiviraux
- Discipline
- Pharmacological treatments
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 2347007
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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DOI
10.1128/AAC.42.7.1568 
https://dx.doi.org/10.1128/AAC.42.7.1568
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