LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
- Auteur
- SHIH, C1 ; CHEN, V. J1 ; ANDIS, S. L1 ; BEWLEY, J. R1 ; RAYL, E. A2 ; MOROSON, B. A2 ; BEARDSLEY, G. P2 ; KOHLER, W3 ; RATNAM, M3 ; SCHULTZ, R. M1 ; GOSSETT, L. S1 ; GATES, S. B1 ; MACKELLAR, W. C1 ; HABECK, L. L1 ; SHACKELFORD, K. A1 ; MENDELSOHN, L. G1 ; SOOSE, D. J1 ; PATEL, V. F1
[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States
[2] Department of Pediatrics, Yale University, New Haven, Connecticut 06510, United States
[3] Department of Biochemistry and Molecular Biology, Medical College of Ohio, Toledo, Ohio 43699, United States - Source
Cancer research (Baltimore). 1997, Vol 57, Num 6, pp 1116-1123 ; ref : 55 ref
- CODEN
- CNREA8
- ISSN
- 0008-5472
- Domaine scientifique
- Medical oncology; Pharmacology drugs
- Editeur
- American Association for Cancer Research, Philadelphia, PA
- Pays de publication
- United States
- Type de document
- Article
- Langue
- English
- Mot clé (fr)
- Anticancéreux Antifolate Cellule tumorale Cytotoxicité Dihydrofolate reductase Homme In vitro Inhibiteur enzyme Lignée cellulaire établie Mécanisme action Phosphoribosylglycinamide formyltransferase Thymidylate synthase LY 231514 Pyrrolo[2,3-d]pyrimidine dérivé Pyrrolopyrimidine dérivé Enzyme Methyltransferases Oxidoreductases Transferases
- Mot clé (en)
- Antineoplastic agent Antifolate Tumor cell Cytotoxicity Dihydrofolate reductase Human In vitro Enzyme inhibitor Established cell line Mechanism of action Phosphoribosylglycinamide formyltransferase Thymidylate synthase Enzyme Methyltransferases Oxidoreductases Transferases
- Mot clé (es)
- Anticanceroso Antifolato Célula tumoral Citotoxicidad Dihydrofolate reductase Hombre In vitro Inhibidor enzima Línea celular establecida Mecanismo acción Phosphoribosylglycinamide formyltransferase Thymidylate synthase Enzima Methyltransferases Oxidoreductases Transferases
- Classification
- Pascal
- 002 Sciences biologiques et medicales / 002B Sciences medicales / 002B02 Pharmacologie. Traitements medicamenteux / 002B02R Anticancéreux / 002B02R01 Généralités
- Discipline
- Pharmacological treatments
- Provenance
- Inist-CNRS
- Base de données
- PASCAL
- Identifiant INIST
- 2612074
Sauf mention contraire ci-dessus, le contenu de cette notice bibliographique peut être utilisé dans le cadre d’une licence CC BY 4.0 Inist-CNRS / Unless otherwise stated above, the content of this bibliographic record may be used under a CC BY 4.0 licence by Inist-CNRS / A menos que se haya señalado antes, el contenido de este registro bibliográfico puede ser utilizado al amparo de una licencia CC BY 4.0 Inist-CNRS
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Accès par Europe PubMed Central
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Accès par Base Search
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