Heat Shock Protein 90: Inhibitors in Clinical TrialsBIAMONTE, Marco A; VAN DE WATER, Ryan; ARNDT, Joseph W et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 3-17, issn 0022-2623, 15 p.Article

6-(Het)aryl-7-Deazapurine Ribonucleosides as Novel Potent Cytostatic AgentsNAUS, Petr; POHL, Radek; CIHLAR, Tomas et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 460-470, issn 0022-2623, 11 p.Article

9-Arylpurines as a Novel Class of Enterovirus InhibitorsAGUADO, Leire; JAN THIBAUT, Hendrik; PRIEGO, Eva-Maria et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 316-324, issn 0022-2623, 9 p.Article

Benzimidazole Derivatives as New Serotonin 5-HT₆ Receptor Antagonists. Molecular Mechanisms of Receptor InactivationDE LA FUENTE, Tania; MARTIN-FONTECHA, Mar; LOPEZ-RODRIGUEZ, Maria L et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1357-1369, issn 0022-2623, 13 p.Article

Benzo[e]isoindole-1,3-diones as Potential Inhibitors of Glycogen Synthase Kinase-3 (GSK-3). Synthesis, Kinase Inhibitory Activity, Zebrafish Phenotype, and Modeling of Binding ModeHAIXIA ZOU; LIYAN ZHOU; YUANZHEN LI et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 994-1003, issn 0022-2623, 10 p.Article

De Novo Design of a Picomolar Nonbasic 5-HT_1B Receptor AntagonistNUGIEL, David A; KRUMRINE, Jennifer R; HILL, Daniel C et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1876-1880, issn 0022-2623, 5 p.Article

Discovery and Optimization of Novel 3-Piperazinylcoumarin Antagonist of Chemokine-like Factor 1 with Oral Antiasthma Activity in MiceGANG LI; DONGMEI WANG; MINGNA SUN et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1741-1754, issn 0022-2623, 14 p.Article

Fructose-1,6-bisphosphatase Inhibitors. 2. Design, Synthesis, and Structure—Activity Relationship of a Series of Phosphonic Acid Containing Benzimidazoles that Function as 5'-Adenosinemonophosphate (AMP) MimicsQUN DANG; SRINIVRAS RAO KASIBHATLA; POTTER, Scott C et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 441-451, issn 0022-2623, 11 p.Article

Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB₂ Cannabinoid Receptor ActivityFROST, Jennifer M; DART, Michael J; ZHU, Chang Z et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 295-315, issn 0022-2623, 21 p.Article

Novel Bisaryl Substituted Thiazoles and Oxazoles as Highly Potent and Selective Peroxisome Proliferator-Activated Receptor δ AgonistsEPPLE, Robert; COW, Christopher; CUC NGO, Cara et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 77-105, issn 0022-2623, 29 p.Article

Novel Synthesis and Structural Characterization of a High-Affinity Paramagnetic Kinase Probe for the Identification of Non-ATP Site Binders by Nuclear Magnetic ResonanceMOY, Franklin J; LEE, Arthur; KRIM GAVRIN, Lori et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1238-1249, issn 0022-2623, 12 p.Article

Selective Inhibitors of the JMJD2 Histone Demethylases: Combined Nondenaturing Mass Spectrometric Screening and Crystallographic ApproachesROSE, Nathan R; WOON, Esther C. Y; SCHOFIELD, Christopher J et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1810-1818, issn 0022-2623, 9 p.Article

Structure—Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral InfectionsJIANGNAN PENG; KUDRIMOTI, Sucheta; KHAN, Shabana I et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 61-76, issn 0022-2623, 16 p.Article

Structure―Activity Relationship Studies Leading to the Identification of (2E)-3-[1-[(2,4-Dichlorophenyl)methyl]-5-fluoro-3-methyl-1H-indol-7-yl]-N-[(4,5-dichloro-2-thienyl)sulfonyl]-2-propenamide (DG-041), a Potent and Selective Prostanoid EP3 Receptor Antagonist, as a Novel Antiplatelet Agent That Does Not Prolong BleedingSINGH, Jasbir; ZELLER, Wayne; SIGTHORSSON, Gudmundur et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 18-36, issn 0022-2623, 19 p.Article

Synthesis and Anticonvulsant Activities of (R)-N-(4'-Substituted)benzyl 2-Acetamido-3-methoxypropionamidesSALOME, Christophe; SALOME-GROSJEAN, Elise; DUK PARK, Ki et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1288-1305, issn 0022-2623, 18 p.Article

Synthesis and Biological Evaluation of New Nanomolar Competitive Inhibitors of Helicobacter pylori Type II Dehydroquinase. Structural Details of the Role of the Aromatic Moieties with Essential ResiduesPRAZERES, Verónica F. V; TIZON, Lorena; OTERO, José M et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 191-200, issn 0022-2623, 10 p.Article

Synthesis and Biological Evaluation of Triazol-4-ylphenyl-Bearing Histone Deacetylase Inhibitors as ticancer AgentsRONG HE; YUFENG CHEN; YIHUA CHEN et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1347-1356, issn 0022-2623, 10 p.Article

Synthesis and Opioid Receptor Binding Affinities of 2-Substituted and 3-Aminomorphinans: Ligands for μ, K, and δ Opioid ReceptorsDECKER, Michael; SI, Yu-Gui; KNAPP, Brian I et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 402-418, issn 0022-2623, 17 p.Article

Synthesis, Biological Evaluation, and Molecular Modeling of 1-Benzyl-1H-imidazoles as Selective Inhibitors of Aldosterone Synthase (CYP11B2)ROUMEN, Luc; PEETERS, Joris W; VEKEMANS, JefA J et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 4, pp 1712-1725, issn 0022-2623, 14 p.Article

The Binding of Synthetic Retinoids to Lipocalin β-LactoglobulinsRIIHIMÄKI-LAMPEN, Laura H; VAINIO, Mikko J; VAHERMO, Mikko et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 514-518, issn 0022-2623, 5 p.Article

Transforming Rhinacanthin Analogues from Potent Anticancer Agents into Potent Antimalarial AgentsKONGKATHIP, Ngampong; PRADIDPHOL, Narathip; CHUAWONG, Pitak et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1211-1221, issn 0022-2623, 11 p.Article

Discovery of 4-(5-Methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a Novel α7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition ModelsO'DONNELL, Christopher J; ROGERS, Bruce N; HURST, Raymond S et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 3, pp 1222-1237, issn 0022-2623, 16 p.Article

Displacement Assay for the Detection of Stabilizers of Inactive Kinase Conformations^tKLÜTER, Sabine; GRÜTTER, Christian; NAQVI, Tabassum et al.Journal of medicinal chemistry (Print). 2010, Vol 53, Num 1, pp 357-367, issn 0022-2623, 11 p.Article

Beyond Picomolar Affinities : Quantitative Aspects of Noncovalent and Covalent Binding of Drugs to ProteinsSMITH, Adam J. T; XIYUN ZHANG; LEACH, Andrew G et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 2, pp 225-233, issn 0022-2623, 9 p.Article

1-Sulfonyl-4-acylpiperazines as Selective Cannabinoid-1 Receptor (CB1R) Inverse Agonists for the Treatment of ObesityVACHAL, Petr; FLETCHER, Joan M; CHEN, Richard Z et al.Journal of medicinal chemistry (Print). 2009, Vol 52, Num 8, pp 2550-2558, issn 0022-2623, 9 p.Article